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. 2021 Feb 8;162(9):2376–2385. doi: 10.1097/j.pain.0000000000002223

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Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Association for the Study of Pain.

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 2. — Time course of plasma AEA levels after NTG administration in MIG and HC groups. T30, T60, and T120: evaluations at 30, 60, and 120 minutes after nitroglycerin (NTG) administration (0.9 mg sublingual). MIG: subjects with episodic migraine (n = 24); HC: healthy controls (n = 19). Statistical analysis: 2-factor ANOVA for repeated measures (factor “GROUP” with 2 levels: MIG vs HC; factor “TIME” with 4 levels: Baseline, T30, T60, T120). TIME: P = 0.022; GROUP: P = 0.779; TIME × GROUP: P = 0.671. Δ = post hoc analysis: P < 0.050 vs Baseline (the color identifies the group). AEA, anandamide; ANOVA, analysis of variance.