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. 2021 Feb 8;162(9):2376–2385. doi: 10.1097/j.pain.0000000000002223

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Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Association for the Study of Pain.

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 8. — Changes in endocannabinoid levels and neurophysiological parameters recorded at migraine onset and 1 hour later in migraine subjects showing a positive response to the migraine-induction test within the 180-minute in-hospital observation period. Data from migraine subjects showing a positive migraine-induction test response within the 180-minute in-hospital observation period (MIG+ subgroup, n = 13). T-MIG: evaluation at migraine onset; T-MIG-1h: evaluation 1 hour after migraine onset. Statistical analysis: 1-factor ANOVA for repeated measures (factor “TIME” with 3 levels: Baseline, T-MIG, T-MIG-1h): AEA (A): TIME: P = 0.184. PEA (B): TIME: P = 0.035. RTh (C): TIME: P = 0.035. TST (D): TIME: P = 0.001. Δ = post hoc analysis: P < 0.050 vs Baseline. AEA, anandamide; ANOVA, analysis of variance; PEA, palmitoylethanolamide; RTh, reflex threshold.