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. 2021 Aug 5;9:658112. doi: 10.3389/fcell.2021.658112

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Copyright © 2021 Sun, Tian, Xue, Ye, Xue, Wang, Liu, Zhang, Chen and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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REV-ERBs agonist SR9009 prevents abnormal follicular development by regulating mitochondrial biosynthesis and autophagy in PCOS animal models. Female Sprague Dawley rats were injected with DHEA to construct the PCOS model, and treated with SR9009 or saline by i.p. twice per day for 1 week and then once a day for a further week. (A) The expression of REV-ERBs was detected by western blotting. (B) Representative images of H&E staining of ovarian tissues from rats in each group. Scale bars: 200 μm. (C) Genes related to mitochondrial biogenesis protein levels in ovarian tissues detected by western blotting. (D) The expression of LC3 and p62 was detected by western blotting.