Table 3.
Ten-Year Outcomes of Uveal Melanoma Based on The Cancer Genome Atlas (TCGA) Classification in 1001 Cases. Outcomes.
| Outcomes | TCGA Class | Total Population | |||||
|---|---|---|---|---|---|---|---|
|
|
|
||||||
| A (n=486) [n (%)] | B (n=141) [n (%)] | C (n=260) [n (%)] | D (n=114) [n (%)] | Odds Ratio (95% Confidence Interval) | P | (n=1001) [n (%)] | |
| Follow-up (months) (median, range) | 46.4 (40.1, <0.1 - 161.0) | 45.0 (33.9, 0.1 - 184.9) | 32.4 (23.9, 0.1 - 173.1) | 32.7 (28.0, 0.0 - 117.4) | --- | <0.001 | 41.0 (30.6, <0.1 - 184.9) |
| Metastasis | 14 (3) | 12 (9) | 53 (20) | 52 (46) |
A vs. B: 2.48 (1.11-5.56)
A vs. C: 6.21 (3.32 - 11.62) A vs. D: 22.25 (11.54 - 42.90) |
0.026
0.027 <0.001 |
131 (13) |
| Mean time to metastasis (months) (median, range) | 37.4 (40.2, 0.5 - 81.0) | 38.7 (38.3, 1.1 - 77.3) | 27.7 (19.1, 0.2 - 85.6) | 21.5 (18.0, 0.0 - 107.2) | --- | 0.009 | 27.3 (19.9, 0.0 - 107.2) |
| Liver metastasis | 10 (2) | 12 (9) | 51 (20) | 52 (46) |
A vs. B: 3.20 (1.32 - 7.74)
A vs. C: 7.32 (3.55 - 15.07) A vs. D: 25.04 (11.81 - 53.11) |
0.026
0.009 <0.001 |
125 (12) |
| Mean time to metastasis (months) (median, range) | 30.2 (22.2, 0.5 - 65.7) | 38.9 (38.3, 1.1 - 77.3) | 26.7 (18.7, 0.2 - 85.6) | 21.9 (18.0, 0.0 - 107.2) | --- | 0.032 | 26.2 (19.5, 0.0 - 107.2) |
| Lung metastasis | 1 (<1) | 2 (1) | 10 (4) | 11 (10) | A vs. B: 4.91 (0.44 - 55.23) A vs. C: 11.50 (1.43 - 92.32) A vs. D: 34.75 (4.40 - 274.59) |
0.615 0.047 <0.001 |
24 (2) |
| Mean time to metastasis (months) (median, range) | 28.4 (28.4, 28.4 - 28.4) | 47.4 (47.4, 17.5 - 77.3) | 31.5 (25.1, 1.3 - 65.7) | 36.8 (37.5, 5.6 - 72.3) | --- | 0.896 | 34.8 (32.9, 1.3 - 77.3) |
| Other metastasis* | 5 (1) | 5 (4) | 13 (5) | 16 (14) | A vs. B: 1.98 (0.53 - 7.37) A vs. C: 2.10 (0.67 - 6.57) A vs. D: 7.30 (2.39 - 22.25) |
0.659 0.709 <0.001 |
39 (4) |
| Mean time to metastasis (months) (median, range) | 48.2 (53.9, 0.5 - 81.0) | 42.8 (50.7, 6.9 - 65.9) | 41.7 (41.8, 13.6 - 73.7) | 35.3 (35.2, 3.6 - 72.3) | --- | 0.263 | 40.2 (43.4, 0.5 - 81.0) |
| Death from UM metastasis | 2 (<1) | 0 (0) | 4 (2) | 8 (7) | A vs. B: na A vs. C: 2.26 (0.36 - 14.07) A vs. D: 9.65 (1.67 - 55.73) |
-- 0.634 0.003 |
14 (1) |
| Mean time to death (months) (median, range) | 48.0 (48.0, 27.2 - 68.8) | 0.0 (0.0, 0.0 - 0.0) | 47.4 (46.0, 38.2 - 59.4) | 26.5 (24.3, 3.5 - 50.5) | --- | 0.097 | 35.5 (38.3, 3.5 - 68.8) |
Bold values indicate significant P. UM = Uveal melanoma, NA= not available. *Sites of other metastasis include bone, brain, breast, intestine, distant lymph nodes, mesentery, muscle, skin