Table 4.
Ten-Year Outcomes for Uveal Melanoma Based on The Cancer Genome Atlas (TCGA) Classification in 1001 Cases. Event-Free Survival Analysis of Metastasis and Death
| Event-Free Survival | TCGA Class | Total Population | |||
|---|---|---|---|---|---|
|
|
|
||||
| A (n=486) [n (%)] | B (n=141) [n (%)] | C (n=260) [n (%)] | D (n=114) [n (%)] | (n=1001) [n (%)] | |
| Overall Metastasis | |||||
| 1 Year | 394 (99) | 123 (98) | 185 (93) | 83 (85) | 785 (96) |
| 2 Years | 315 (98) | 92 (97) | 118 (85) | 52 (64) | 577 (91) |
| 5 Years | 160 (96) | 40 (88) | 41 (67) | 12 (40) | 254 (82) |
| 10 Years | 16 (94) | 6 (80) | 5 (51) | NA | 27 (75) |
| Liver Metastasis | |||||
| 1 Year | 394 (99) | 123 (98) | 185 (93) | 83 (86) | 785 (96) |
| 2 Years | 315 (98) | 92 (97) | 118 (85) | 52 (65) | 577 (91) |
| 5 Years | 160 (98) | 40 (88) | 41 (67) | 12 (42) | 254 (82) |
| 10 Years | 17 (96) | 6 (80) | 5 (55) | NA | 28 (77) |
| Lung Metastasis | |||||
| 1 Year | 394 (100) | 123 (100) | 195 (99) | 91 (99) | 801 (>99) |
| 2 Years | 316 (100) | 91 (>99) | 130 (97) | 64 (95) | 601 (99) |
| 5 Years | 161 (99) | 41 (99) | 42 (93) | 13 (76) | 257 (96) |
| 10 Years | 17 (99) | 6 (95) | 5 (89) | NA | 28 (94) |
| Other Metastasis* | |||||
| 1 Year | 394 (>99) | 121 (99) | 196 (100) | 92 (99) | 802 (>99) |
| 2 Years | 316 (>99) | 91 (99) | 131 (99) | 64 (93) | 604 (99) |
| 5 Years | 160 (98) | 40 (95) | 42 (88) | 14 (71) | 256 (93) |
| 10 Years | 16 (97) | 6 (90) | 5 (83) | NA | 27 (90) |
| Death from Uveal Melanoma | |||||
| 1 Year | 394 (100) | 123 (100) | 196 (100) | 92 (99) | 802 (>99) |
| 2 Years | 316 (100) | 92 (100) | 131 (100) | 66 (96) | 604 (99) |
| 5 Years | 162 (>99) | 41 (100) | 42 (93) | 14 (85) | 259 (97) |
| 10 Years | 17 (99) | 6 (100) | 5 (93) | NA | 28 (97) |
TCGA=The Cancer Genome Atlas, NA=not available. *Sites of other metastasis include bone, brain, breast, intestine, distant lymph nodes, mesentery, muscle, skin