Figure 1.

Comprehensive multi-platform analysis of uveal melanoma unravels four molecularly distinct, clinically relevant subtypes: two associated with poor-prognosis monosomy 3 and two with better-prognosis disomy 3. Two subsets of disomy 3 are based on EIF1AX or SF3B1 mutations with consequent somatic copy number alterations and DNA methylation profiles. BAP1 aberration and global DNA methylation are seen to be associated with monosomy 3. Two subsets of monosomy 3 are based on genomic aberrations and transcriptional features. There is a linear increase in metastatic risk from subtype 1 through 4. Reproduced with permission from Robertson AG, Shih J, Yau C, Gibb EA, Oba J, Mungall KL, et al. Integrative analysis identifies four molecular and clinical subsets in uveal melanoma. Cancer Cell. 2017;32:204-220