Table 1.

Four groups of uveal melanoma based on The Cancer Genome Atlas classification[15,16]

Group	Genetic/molecular Profile	Prognosis
Group A	mRNA class 1, infrequent chromosomal aberrations, disomy 3, extra 6p, normal 8q, no inflammation	Favorable
Group B	mRNA class 1, infrequent chromosomal aberrations, disomy 3, extra 6p, partial extra 8q, no inflammation	Less favorable
Group C	mRNA class 2, frequent chromosomal aberrations, monosomy 3, extra 8q, some inflammation	Unfavorable
Group D	mRNA class 2, frequent chromosomal aberrations, monosomy 3, >>extra 8q, severe inflammation	Unfavorable

Adapted from Jager MJ, Brouwer NJ, Esmaeli B. The Cancer Genome Atlas Project: an integrated molecular view of uveal melanoma. Ophthalmology. 2018;125:1139-1142