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. 2021 Aug 17;218(10):e20210250. doi: 10.1084/jem.20210250

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© 2021 Beilinson et al.

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Figure 5. — D_H and J_H gene segment usage in VDJ_H rearrangements in bone marrow assessed by ImmunoSEQ. (A–C) ImmunoSEQ data from mice 5–7 wk of age were analyzed for frequency of DFL16.1 (blue), DQ52 (salmon), and intervening 11 D_H gene segments (green) in total or nonproductive VDJ_H rearrangements (A) or VDJ_H rearrangements to individual J_H gene segments (B) and for J_H gene segments in total and nonproductive VDJ_H recombination events (C). Percentage of DQ52 usage is indicated above each bar in A and B. n, number of mice analyzed per genotype. Number of recombination events analyzed can be found in Table S7. Data are presented as mean with error bars indicating SEM. Statistical significance relative to WT determined by two-tailed unpaired t tests (ns, P > 0.05; *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001; ****, P ≤ 0.0001).