Post-operative analysis of ACLR patients (top row) and virtual ACLR models (bottom row) were used to investigate the link between graft tunnel location and angles and knee mechanics. ACL geometries were reconstructed from MRIs to assess footprint locations and graft angle. Bilateral anterior knee laxity was evaluated at clearance from rehabilitation. Tibiofemoral kinematics during active knee motion were measured using dynamic MRI. For computational modeling, 500 virtual ACLR models were created by randomly varying the graft footprint locations, stiffness, and initial tension. An anterior knee laxity test, active knee extension, and walking were simulated for each virtual ACLR model.