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An imbalance in a dynamic equilibrium of bone remodeling leads to osteoporosis. Bone homeostasis is maintained by an equal amount of bone formation, and bone resorption carried out by osteoblast (OB) and osteoclast (OC). Under the influence of various mediators and cellular components, the equilibrium shifts towards greater bone resorption due to exacerbated osteoclast activity. This leads to a decrease in bone mineral density and causes osteoporosis.
