Skip to main content
. 2021 Aug 5;12:692729. doi: 10.3389/fimmu.2021.692729

Figure 2.

Figure 2

BCG induces broad cross-reactive T cell responses across individuals. Heat map of individuals representing global HLA coverage shows improved SARS-CoV-2 T cell responses when pre-stimulated with BCG peptide. Individual donor T cell responses to the 8 peptide pairs (PP1-PP8) across 11 parameters (i-xi) determined by flow cytometry. i–CD8+IFN-γ, ii–CD8+TNF, iii–CD8+IL-2, iv–CD8+CD69, v–CD8+Perforin, vi–CD8+proliferation, vii–CD4+IFN-γ, viii–CD4+TNF, ix–CD4+IL-2, x–CD4+CD69, xi–CD4+proliferation. A responder (red) is defined as showing a positive response after subtraction of the control-primed response to SARS-CoV-2. A non-responder (white) is defined as showing no positive staining after subtraction of the control response. Grey –no data. Individuals were grouped by known or unknown HLA-type highlighting similar patterns between them.