Table 5.

Univariate and Multivariate Backward Stepwise Logistic Regression Analysis for High PWV (PWV ≥ 1400 cm/s) in NTG Group

	Univariate			Multivariate
	Odds Ratio	95% CI	P Value	Odds Ratio	95% CI	P Value
Age, years	1.153	1.083–1.229	<0.001	1.228	1.113–1.356	<0.001
Sex, male	2.074	0.932–4.615	0.074
Body mass index (kg/m2)	0.921	0.805–1.054	0.233
Systolic BP (mmHg)	1.123	1.070–1.178	<0.001
Diastolic BP (mmHg)	1.099	1.045–1.155	<0.001
Mean arterial pressure (mmHg)	1.131	1.071–1.194	<0.001	1.221	1.112–1.341	<0.001
HbA1c (%)	1.611	1.003–2.589	0.049
Total cholesterol (mg/dL)	0.990	0.980–0.999	0.034
Triglycerides (mg/dL)	1.000	0.995–1.004	0.859
HDL cholesterol (mg/dL)	0.984	0.952–1.018	0.353
LDL cholesterol (mg/dL)	0.987	0.976–0.998	0.020
eGFR (ml/min)	0.948	0.919–0.978	0.001
Uric acid (mg/dL)	0.815	0.628–1.058	0.124
Intraocular pressure (mmHg)	1.220	0.991-1.503	0.061
Axial length (mm)	0.675	0.498–0.915	0.011
Spherical equivalent (diopters)	1.214	1.041–1.417	0.014
Average RNFL thickness (µm)	0.985	0.954–1.017	0.356
Average GCIPL thickness (µm)	0.977	0.931–1.025	0.341
Peripapillary VD (mm−1)	0.750	0.570–0.988	0.041
Macular VD (mm−1)	0.605	0.461–0.796	<0.001	0.655	0.445–0.964	0.032
Hosmer-Lemeshow P value: 0.595
Nagelkerke R2 = 0.672

Variables with P values less than 0.2 during the univariate step were further enrolled in a backward stepwise logistic regression model.

PWV: pulse wave velocity; NTG: normal-tension glaucoma; BP: blood pressure; HbA1c: hemoglobin A1c; HDL: high-density lipoprotein; LDL: low-density lipoprotein; eGFR: estimated glomerular filtration rate; RNFL: retinal nerve fiber layer; GCIPL: ganglion cell–inner plexiform layer; VD: vessel density.