Figure 1.

Functional analysis. DAVID algorithm was applied to identify functional protein clusters in the AH. Functional annotations were detected from multiple databases including UniProt, Gene Ontology (GO) (see Method section). The functional analysis was performed on the total proteins discovered in AH according to MS1 (11 clusters) (A), and on proteins which were upregulated in nvAMD (six clusters) (B). Association of nvAMD and the functional clusters was confirmed by χ² test as compared to randomized protein clusters. Three clusters showed differential expression in this analysis (B). * indicates P < 0.05.