Table 1.

Comparison of Previous Unbiased Proteomic Studies of AH and Vitreous in AMD (The Full List of the Proteins Presented in Supplementary Table S3)

Study	Rinsky et al. (2021)	Kim et al. (2012)	Koss et al. (2016)	Siwy et al. (2014)
Source of Sample	Aqueous	Aqueous	Vitreous	Vitreous
Mass spectrometry analysis
AMD patients	10	3	72	73
Controls	10	3	16	15
Total proteins identified	674	154	101	97
Proteins upregulated in AMD	239	52	4 (up or down)	19
Proteins upregulated in control	86	22
Overlap with Rinsky et al.	N/A
Validation set and potential biomarkers *
AMD patients	30**	6	36	4
Controls	20	5	8	4
Number of proteins tested	9	7	4	5
AMD Proteins Overlaping	6 discovered in this study	10 new proteins compared to previous studies	40	8

^**aAMD and nvAMD.