Table 1.
Baseline Characteristics of the Adult Study Population
| Cohort | |||||||
|---|---|---|---|---|---|---|---|
| RS1 | RS2 | RS3 | RS Total | MYST – Cases | MYST–Controls | Total Adults | |
| Total population N | 6835 | 3011 | 3932 | 13778 | 1047 | 17553 | |
| Genotype and SER known | 5785 | 2047 | 2960 | 10729 | 462 | 380 | 11634 |
| Risk allele (% A) | 48.3 | 47.5 | 47.8 | 48.0 | 55.1 | 44.8 | 48.2 |
| TT | 1560 (27.0) | 570 (27.8) | 812 (27.4) | 2942 (27.3) | 116 (21.2) | 126 (31.7) | 3160 (27.2) |
| AT (one risk allele) | 2865 (49.5) | 1009 (49.3) | 1465 (49.5) | 5339 (49.5) | 258 (47.3) | 187 (47.0) | 5736 (49.3) |
| AA (two risk alleles) | 1360 (23.5) | 468 (22.9) | 683 (23.1) | 2511 (23.3) | 172 (31.5) | 85 (21.4) | 2738 (23.5) |
| Age (y), N | 5785 | 2047 | 2960 | 10729 | 462 | 380 | 11634 |
| Mean (SD) | 68.8 (8.8) | 64.4 (7.5) | 57.1 (6.5) | 64.8 (9.4) | 45.9 (12.6) | 49.2 (12.5) | 63.6 (10.7) |
| Range | 55.1–99.3 | 55.2–95.5 | 45.7–90.1 | 45.7–99.3 | 16.73–79.62 | 16.73–79.62 | 16.73–99.27 |
| Sex (% men) | 2350 (40.6) | 940 (45.9) | 1303 (44.0) | 4591 (42.5) | 182 (39.4) | 174 (45.8) | 4947 (42.5) |
| Education, N | 5703 | 2027 | 2950 | 10680 | 448 | 364 | 11492 |
| Primary education (%) | 1339 (41.2) | 150 (7.4) | 303 (10.3) | 1792 (16.8) | 8 (1.8) | 4 (1.1) | 1804 (15.7) |
| Lower education (%) | 2351 (41.2) | 942 (46.5) | 1061 (36.0) | 4354 (40.8) | 32 (7.1) | 51 (14.0) | 4437 (38.6) |
| Intermediate education (%) | 1545 (27.1) | 594 (29.3) | 804 (27.3) | 2943 (27.6) | 103 (23.0) | 105 (28.8) | 3154 (27.4) |
| Higher education (%) | 468 (22.3) | 341 (16.8) | 782 (26.5) | 1591 (14.9) | 305 (68.1) | 204 (56.0) | 2100 (18.3) |
| SER (D), mean (SD) | 0.83 (2.59) | 0.48 (2.51) | −0.29 (2.59) | 0.46 (2.60) | −10.4 (3.38) | −0.50 (1.77) | −0.004 (2.26) |
| Range | −19.13 to 15.13 | −15.25 to 10.50 | −16.13 to 9.13 | −19.13 to 15.13 | −23.88 to 6.00 | −5.94 to 4.00 | −23.88 to 15.13 |
| Myopia (%)* | 1111 (19.2) | 505 (24.7) | 1091 (36.9) | 2707 (25.1) | 462 (100) | 126 (33.2) | 3295 (28.3) |
| High myopia (%)† | 111 (1.9) | 36 (1.8) | 87 (2.9) | 234 (2.2) | 462 (100) | 0 (0) | 696 (6.0) |
| Biometry, N | 915 | 1238 | 2635 | 4788 | 544 | 398 | 5730 |
| AL (mm), N | 915 | 1238 | 2635 | 4788 | 544 | 398 | 5730 |
| Mean (SD) | 23.49 (1.24) | 23.53 (1.19) | 23.74 (1.30) | 23.64 (1.27) | 27.56 (1.72) | 23.89 (1.33) | 24.03 (1.74) |
| Range | 15.49–31.29 | 19.87–31.35 | 18.96–31.30 | 15.49–31.35 | 24.22–37.58 | 21.15–33.24 | 15.49–37.58 |
| LT (mm), N | 682 | 1075 | 2492 | 4249 | 459 | 378 | 5086 |
| Mean (SD) | 4.81 (0.44) | 4.62 (0.38) | 4.49 (0.39) | 4.58 (0.41) | 4.10 (0.40) | 4.18 (0.37) | 4.50 (0.44) |
| Range | 3.79–6.66 | 2.61–6.04 | 3.19–6.29 | 2.61–6.66 | 1.92–5.16 | 2.56–5.18 | 1.92–6.66 |
| CT (µm), N | 567 | 1216 | 2391 | 4174 | 543 | 396 | 5113 |
| Mean (SD) | 547.15 (34.61) | 547.66 (34.17) | 550.28 (33.92) | 549.09 (34.11) | 542.33 (37.35) | 545.02 (35.87) | 548.0 (34.7) |
| Range | 450.00–678.50 | 443.00–669.00 | 404.00–691.00 | 404.00–691.00 | 454.50–718.00 | 387.50–645.50 | 387.5–718.0 |
| CR (radius mm), N | 1493 | 1277 | 2396 | 5166 | 546 | 398 | 6115 |
| Mean (SD) | 7.72 (0.26) | 7.73 (0.25) | 7.75 (0.27) | 7.74 (0.26) | 7.73 (0.28) | 7.79 (0.32) | 7.75 (0.30) |
| Range | 6.94–8.61 | 6.93–8.52 | 7.03–9.08 | 6.93–9.08 | 6.76–9.08 | 6.66–10.20 | 6.66–10.20 |
| AL/CR, N | 915 | 1238 | 2394 | 4778 | 544 | 398 | 5486 |
| Mean (SD) | 3.03 (0.16) | 3.05 (0.15) | 3.07 (0.16) | 3.05 (0.16) | 3.57 (0.20 | 3.07 (0.17) | 3.11 (0.22) |
| Range | 1.98–4.14 | 2.44–3.92 | 2.54–4.03 | 1.98–4.14 | 3.00–4.81 | 2.75–4.69 | 1.98–4.81 |
| ACD (mm), N | 733 | 1103 | 2524 | 4360 | 515 | 389 | 5264 |
| Mean (SD) | 2.75 (0.61) | 2.66 (0.47) | 2.68 (0.37) | 2.68 (0.44) | 3.08 (0.43) | 2.82 (0.38) | 2.73 (0.45) |
| Range | 1.64–5.25 | 1.60–5.43 | 1.50–5.17 | 1.50–5.43 | 1.81–5.07 | 1.99–4.83 | 1.50–5.43 |
| VD (mm), N | 420 | 1054 | 2265 | 3739 | 494 | 384 | 4616 |
| Mean (SD) | 15.76 (1.00) | 15.74 (1.06) | 16.13 (1.18) | 16.00 (1.14) | 19.79 (1.63) | 16.32 (1.17) | 16.41 (1.68) |
| Range | 12.56–18.80 | 13.03–21.15 | 12.32–23.53 | 12.32–23.53 | 16.71–26.56 | 13.78–23.89 | 12.32–26.56 |
| Lens power mS (D), N | 718 | 1086 | 2490 | 4294 | 457 | 374 | 5125 |
| Mean (SD) | 19.62 (2.11) | 19.26 (1.73) | 19.79 (1.91) | 19.63 (1.91) | 20.16 (1.85) | 20.52 (2.10) | 19.76 (1.95) |
| Range | 13.73–26.95 | 13.44–27.08 | 12.70–26.61 | 12.70–27.08 | 12.78–26.42 | 12.94–26.15 | 12.70–27.08 |
| Lens power BR (D), N | 718 | 1086 | 2490 | 4294 | 457 | 374 | 5125 |
| Mean (SD) | 19.47 (2.09) | 19.11 (1.71) | 19.64 (1.89) | 19.48 (1.89) | 20.25 (1.87) | 20.68 (2.12) | 19.61 (1.93) |
| Range | 13.63–26.71 | 13.44–26.84 | 12.60–26.37 | 12.60–26.84 | 12.83–26.60 | 13.04–26.35 | 12.60–26.84 |
mS, modified Stenström; BR, Bennett-Rabbetts.
*
Myopia was defined as SER ≤ −0.5D.
†
High myopia was defined as SER ≤ −6D.