Table 4.
Effect of GJD2 Genotype (rs524952) on Refractive Error and Biometric Measurements in the Children Population
| Homozygous | Homozygous | Beta GJD2 | |||
|---|---|---|---|---|---|
| Eye | Risk | Heterozygous | Reference | (rs524952) | |
| Measurement | Allele (AA) | (AT) | Allele (TT) | Genotype* | P Value |
| Age 6 | N = 956 | N = 2094 | N = 1082 | ||
| Myopia (% yes) | 26 (2.7) | 48 (2.3) | 18 (1.7) | 0.324 (0.28), 0.529 (0.31)† | 0.235, 0.247 |
| SER (D) | — | — | — | — | — |
| AL (mm) | 22.39 (0.75) | 22.38 (0.76) | 22.34 (0.73) | 0.041 (0.016) | 0.009 |
| CR (radius mm) | 7.77 (0.26) | 7.78 (0.26) | 7.78 (0.26) | −0.001 (0.006) | 0.897 |
| AL/CR | 2.88 (0.078) | 2.88 (0.081) | 2.87 (0.079) | 0.006 (0.002) | 3.11 × 10−4 |
| ACD (mm) | 3.32 (0.33) | 3.31 (0.31) | 3.31 (0.34) | 0.008 (0.008) | 0.305 |
| Age 9 | N = 789 | N = 1702 | N = 899 | ||
| Myopia (%yes) | 106 (13.4) | 190 (11.2) | 96 (10.7) | 0.051 (0.13), 0.265 (0.150)† | 0.698, 0.078 |
| SER (D) | 0.64 (1.4) | 0.73 (1.3) | 0.77 (1.3) | −0.064 (0.050) | 0.194 |
| AL (mm) | 23.16 (0.85) | 23.12 (0.84) | 23.08 (0.83) | 0.054 (0.019) | 0.005 |
| CR (radius mm) | 7.78 (0.26) | 7.79 (0.26) | 7.80 (0.26) | −0.006 (0.006) | 0.346 |
| AL/CR | 2.98 (0.096) | 2.97 (0.094) | 2.96 (0.097) | 0.009 (0.002) | 3.92 × 10−5 |
| ACD (mm) | 3.59 (0.26) | 3.57 (0.25) | 3.56 (0.27) | 0.021 (0.006) | 0.001 |
| AL elongation (mm) | 0.42 (0.18) | 0.41 (0.18) | 0.41 (0.17) | 0.005 (0.004) | 0.288 |
| Lens power mS (D) | 23.25 (1.42) | 23.38 (1.53) | 23.32 (1.56) | −0.069 (0.054) | 0.207 |
| Lens power BR (D) | 23.29 (1.41) | 23.39 (1.53) | 22.34 (1.59) | −0.059 (0.057) | 0.301 |
| ERS | −0.0055 (0.95) | 0.035 (1.00) | −0.0087 (1.07) | −0.007 (0.031) | 0.813 |
Values are shown as mean (SD). N is the number of individuals with available myopia diagnosis per genotype.
mS, modified Stenström; BR, Bennett-Rabbetts.
*
Calculated using linear regression analysis, adjusted for age and sex.
†
Calculated using logistic regression analysis, adjusted for age and sex: AT vs. TT and AA vs. T.