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. 2021 Aug 19;20:103. doi: 10.1186/s12943-021-01404-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — circPLCE1 inhibits CRC cell proliferation and metastasis in vitro. A Colony formation assays of circPLCE1 transfected HCT8 and DLD1 cells, n = 3. B Sphere formation assays of circPLCE1 transfected HCT8 and DLD1 cells, n = 3. Scale bar = 500 μm. C Anchorage-independent growth of circPLCE1 transfected HCT8 and DLD1 cells, n = 3. Scale bar = 200 μm. D Patient-derived organoids (PDOs) growth with circPLCE1 transfection, n = 3. Scale bar = 200 μm. E migration assays of circPLCE1 transfected HCT8 and DLD1 cells, n = 3. Scale bar = 100 μm. F wound-healing assays of circPLCE1 transfected HCT8 and DLD1 cells, n = 3. Scale bar = 100 μm. G Colony formation assays of circPLCE1 knockdown HCT8 and DLD1 cells, n = 3. H Sphere formation assays of circPLCE1 knockdown HCT8 and DLD1 cells, n = 3. Scale bar = 500 μm. I Anchorage-independent growth of circPLCE1 knockdown HCT8 and DLD1 cells, n = 3. Scale bar = 200 μm. J migration assays of circPLCE1 knockdown HCT8 and DLD1 cells, n = 3. Scale bar = 100 μm. K wound-healing assays of circPLCE1 knockdown HCT8 and DLD1 cells, n = 3. Scale bar = 100 μm. Values are represented as mean ± SD. **p < 0.01, ***p < 0.001, by 2-tailed Student’s t test (A-F) and one-way ANOVA (G-K)