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. 2021 Aug 8;6(32):21071–21086. doi: 10.1021/acsomega.1c02811

Table 1. Amounts of MATYPd Catalyst for the Synthesis of Pyrazole-4-Carbonitrile Derivatives 4a–ob.

entry catalyst (mol %) yield (%)a entry catalyst (mol %) yield (%)a
1 3 16 5 8 84
2 5 38 6 9 93
3 6 57 7 10 97
4 7 77 8 11 97
a

Isolated yields based on 4a.

b

Reaction conditions: 1a (1 mmol), 2 (1. mmol), and 3 (1 mmol) in water were heated at 80 °C under ultrasonic irradiation condition for 15 min.