Table 1. Amounts of MATYPd Catalyst for the Synthesis of Pyrazole-4-Carbonitrile Derivatives 4a–ob.
entry | catalyst (mol %) | yield (%)a | entry | catalyst (mol %) | yield (%)a |
---|---|---|---|---|---|
1 | 3 | 16 | 5 | 8 | 84 |
2 | 5 | 38 | 6 | 9 | 93 |
3 | 6 | 57 | 7 | 10 | 97 |
4 | 7 | 77 | 8 | 11 | 97 |
Isolated yields based on 4a.
Reaction conditions: 1a (1 mmol), 2 (1. mmol), and 3 (1 mmol) in water were heated at 80 °C under ultrasonic irradiation condition for 15 min.