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. 2021 Aug 8;6(32):21071–21086. doi: 10.1021/acsomega.1c02811

Table 2. Effect of Solvents on Synthesis of Pyrazole-4-Carbonitrile Derivatives 4a–o.

solventb time (min) yield (%)a
DCM 120 40
DMF 120 47
THF 120 53
CH3CN 120 42
CHCl3 120 49
MeOH 40 76
ACOH 40 75
EtOH 15 92
H2O 15 97
a

Isolated yields based on 4a.

b

Reaction conditions: 1a (1 mmol), 2 (1 mmol), 3 (1 mmol), and catalyst (0.1 mmol) in water were heated at 80 °C under ultrasonic irradiation condition for 15 min.