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. 2021 Aug 19;21:436. doi: 10.1186/s12935-021-02143-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Silencing of BCL10 significantly inhibited tumor growth of PDAC in a xenograft model. a Approximately 1 × 10⁶ scrambled (Scr) PANC-1 cells and shBCL10-treated PANC-1 cells were implanted subcutaneously into both flanks of NOD/SCI D mice. Representative image shows that the xenograft tumor size was suppressed in shBCL10-treated group. Mice were sacrificed 6 weeks after implantation. Scale bar: 10 mm. b The shBCL10-treated group resulted in 78% reduction of xenograft tumor volume compared with scrambled group. The results of tumor volume are expressed as n = 6 in each treatment group and measured each week. ***p < 0.001, compared to scrambled group. c There is almost no difference in body weight between scrambled group and shBCL10-transfected group. d The expression patterns of BCL10, BCL3, and NF-κB in tumor samples of PANC-1-xenograft model (upper panel, scrambled group; lower panel, shBCL10-treated group). PDAC pancreatic ductal adenocarcinoma