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. 2021 Aug 19;22:58. doi: 10.1186/s12865-021-00449-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — CD39 expression by Treg from colon adenocarcinoma patients. Frequencies of CD39⁺ Treg among total Treg, were determined by flow cytometry in single cell suspensions from tumors, unaffected colon tissue and peripheral blood. Colon tumors were divided into two groups based on CD39 expression by isolated intratumoral Treg, i.e. group I tumors (≥ 75% of CD39-expressing cells among intratumoral Treg) and group II tumors (< 75% of CD39-expressing cells among intratumoral Treg). A Representative FACS-plots, depicting CD39 expression by Treg from one group I tumor and one group II tumor, and a compilation of individual data points from the different locations (n = 40–44), with tumor-infiltrating Treg color-coded with red (group I) and blue (group II). B Lymphocytes isolated from group I and II tumors were analyzed for frequencies of total Treg among intratumoral CD4⁺ T cells. C MFI of Foxp3 expression (n = 36), shown as the MFI ratio of Foxp3 expression, between CD39⁺ and CD39⁻ Treg in patients belonging to group I and II. Symbols represent individual values and horizontal lines the median. Individual values are color-coded in red (group I) and blue (group II). **p < 0.01, ****p < 0.0001