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. 2021 Aug 19;21:933. doi: 10.1186/s12885-021-08669-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — circEIF3K depletion in CAF led to attenuated CRC progression. A circEIF3K expression levels were shown in CAFs stably transfected with sh-NC, sh-circEIF3K-1, sh-circEIF3K-2 by RT-qPCR. ***p < 0.001. B and C Cell proliferation of HCT116 or SW620 cells incubated with CM of CAFs stably transfected with sh-NC, sh-circEIF3K-1, sh-circEIF3K-2 by cell colony formation assay under hypoxia. ***p < 0.001. D and E The invasion of HCT116 or SW620 cells incubated with CM of CAFs stably transfected with sh-NC, sh-circEIF3K-1, sh-circEIF3K-2 were determined by transwell assay under hypoxia. ***p < 0.001. F and G Tube lengths of HDLEC cells (sh-NC-CM, sh-circEIF3K-1-CM, sh-circEIF3K-2-CM) were measured by tube formation assay under hypoxia. ***p < 0.001. H and I Cell proliferation of HCT116 or SW620 cells incubated with exosomes derived from CAFs stably transfected with sh-NC, sh-circEIF3K-1, sh-circEIF3K-2 by cell colony formation assay under hypoxia. ***p < 0.001