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. 2021 Aug 19;21:933. doi: 10.1186/s12885-021-08669-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — miR-214 was key for hypoxia-induced tumorigenesis of CRC. A StarBase 2.0 predicted the interaction between circEIF3K and miR-214. B miR-214 levels were examined by RT-qPCR in HCT116 cells stably transfected with sh-NC or sh-circEIF3K-1. ***p < 0.001. C miR-214 expression levels were detected by RT-qPCR in HCT116 cells treated with mock-CM, hypoxia-CM, hypoxia-CM + miR-214 mimic. ***p < 0.001. D and E Cell proliferation of HCT116 cells treated with mock-CM, hypoxia-CM, hypoxia-CM + miR-214 mimic were examined by cell colony formation assay. ***p < 0.001. F and G Invasion of HCT116 cells treated with mock-CM, hypoxia-CM, hypoxia-CM + miR-214 mimic were measured by transwell assay. ***p < 0.001. H and I Tube lengths of HDLEC cells (mock-CM, hypoxia-CM, hypoxia-CM + miR-214 mimic) were measured by tube formation assay. ***p < 0.001