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. 2021 Aug 19;40:260. doi: 10.1186/s13046-021-02052-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — BBSKE synergistically increased the cytotoxicity of oxaliplatin in gastric cancer cells. a-b SGC-7901 and MGC-803 cells were treated with BBSKE and oxaliplatin alone or in combination with the indicated concentrations. At 24 h after treatment, the cell viability was determined by CCK8 assay. c-d The combination index (CI) values of BBSKE combined with oxaliplatin were calculated using the calcusyn software. e-g SGC-7901 and MGC-803 cells were treated with BBSKE and oxaliplatin alone or in combination with the indicated concentrations. At 24 h after treatment, the percentage of cell apoptosis was determined by Annexin-V/PI staining and flow cytometry, and the percentage of apoptotic cells in the treatment groups was calculated. (* p < 0.05, ** p < 0.01)