Figure 9.

Schematic representation of a working model that depicts how NCTD prevents renal interstitial fibrosis by targeting the Sp1/Gm26669 axis. Following the stimulation of renal tubular epithelial cell by TGF-β1, Sp1 undergoes nuclear translocation and then combines with the promoter of the lncRNA Gm26669 to promote its transcription, thus leading to aggravation of renal interstitial fibrosis. NCTD reduces the expression of lncRNA Gm26669 by inhibiting the nuclear translocation of Sp1, thereby preventing renal interstitial fibrosis.