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. 2021 Jul 13;17(12):3000–3012. doi: 10.7150/ijbs.60866

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Mass spectrometry (MS) detection of differentially secreted proteins in OL-N.C. and OL-shSec23a supernatant. (A) quantification of differentially down-regulated secretory proteins; (B) STRING database analysis derived protein-protein interaction (PPI) network of the 28 down-regulated secretory proteins; (C) correlation of 28 down- regulated secretory proteins and Sec23a from TCGA analysis of melanoma datasets; (D) expression of Pf4 and Ppbp between melanoma cells and melanocyte in GSE22301; (E) expression of Pf4 and Ppbp between low- and high-metastatic melanoma cells in GSE114380; (F) expression of Pf4 and Ppbp between in OL vs POL cells; (G) expression of Pf4 in OL vs OL-shSec23a; (H) validation of the Pf4 down-regulation in OL-shSec23a and POL cells using conditioned medium, respectively. (I) Quantitative analysis of the expressions of Pf4 in the supernatants of OL-N.C.,OL-shSec23a,OL and POL cells (*p<.05,**p<.01,***p<.001).