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. 2021 Jul 13;17(12):3000–3012. doi: 10.7150/ijbs.60866

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Alteration of secreted PF4 affects the invasive behavior of melanoma cells. Neutralization of PF4 with PF4 antibody (10ug/ml) reversed the inhibitory effect of Pf4 on OL (A, C) and POL-Sec23a-OE (B, D) cell migration and invasion; Recombinant PF4 protein (450 ng/ml) treatment inhibited POL cell (E, G); and augmented OL-shSec23a cell (F, H) migration and invasion. (I, J) Recombinant PF4 protein (450 ng/ml) treatment prevented Pf4 down regulation-induced increase in colony formation in POL and OL-shSec23a cells (*p<.05, **p<.01,***p<.001).