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ERK inhibition circumvents resistance to mTOR blockade. (A, C) Rapamycin-resistant A549 and H1650 cells were generated by exposing the parental cells to rapamycin (4μM) for continuous 3 months, and the expressions of p-AKT, AKT, p-mTOR, mTOR, p-ERK, ERK were determined by western blots. (B, D) The parental or rapamycin-resistant NSCLC cells were treated by 500 nM rapamycin or 50 nM trametinib, and cells were stained by crystal violet.
