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. 2021 Jul 25;17(12):3211–3223. doi: 10.7150/ijbs.62752

Figure 5.

Figure 5

Trametinib synergized with rapamycin to promote apoptosis in NSCLC cells. (A) A549, PC9 and H1650 cells were treated with 50 nM rapamycin alone, or 50 nM trametinib alone, or in combination for 48 hours, and the apoptotic cells were measured by flow cytometry analysis. (B) Western blot analyses of PARP and cleaved PARP in NSCLC cells treated with 50 nM rapamycin alone, or trametinib alone, or in combination for 48 hours. Representative data were shown from three independent replicates. Error bars represent mean ± SD, ***P < 0.001.