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Schematic of ATM signaling pathway upon oxidative stress induced autophagy. Under metabolic stress conditions, mitochondria and peroxisomes can cause an increase in ROS production. ATM can act as a sensor of ROS to promote the formation of autophagosome membranes through ATM/CHK2/Beclin 1 and ATM/LKB1/AMPK/TSC2/mTOR pathways, promote mitophagy through ATM/CHK2/p53/ADH5 pathways, and enhance pexophagy through ATM/PEX5/p62 pathway.
