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The regulatory network composed of NOTCH/Jagged and miR34/miR200 regulates the plasticity of partial EMT in SCC. A: Notch binds to an external ligand (Delta/jagged), resulting in the cleavage and release of Notch that produces NICD. NICD translocates to the nucleus, activates Notch and Jagged in transcription, and inhibits Delta at the same time. B: The EMT circuit contains miR-34, miR-200 and Snail, ZEB, which inhibit each other.
