Table 1.
Cytotoxicity Profiles of Naproxen Platinum(IV) Complexes Toward Four Carcinoma Cell Lines, and One Normal Human Cell Line Expressed as IC50 (μM)
| Compounds | ALog Pa | SKOV-3 (48 h) | SKOV-3 (72 h) | CT-26 (48 h) | A549 (48 h) | A549R (48 h) | RFb | Average IC50 (48 h)c | LO-2 (48 h) | SId |
|---|---|---|---|---|---|---|---|---|---|---|
| 130 | 6.263 | 11.3±0.8 | 15.4±0.4 | 8.2±0.6 | 10.2±1.0 | 12.0±0.4 | 1.2 | 10.4 | 15.3±2.5 | 1.5 |
| 1-NPs | /e | 3.8±0.5 | 2.9±0.3 | 2.3±0.4 | 9.7±2.1 | 3.6±0.7 | 0.4 | 4.8 | 18.7±4.6 | 3.9 |
| 2 | 6.182 | 0.08±0.01 | 0.11±0.02 | 0.32±0.07 | 0.14±0.04 | 0.04±0.01 | 0.3 | 0.14 | 0.09±0.01 | 0.7 |
| 2-NPs | / | 0.8±0.1 | 0.6±0.1 | 1.0±0.2 | 1.5±0.2 | 1.0±0.3 | 0.7 | 1.1 | 3.3±0.4 | 3.0 |
| Npx | 2.849 | / | >100 | >100 | >100 | / | / | >100 | / | |
| Vehicle | / | >100 | >100 | >100 | >100 | / | / | >100 | / | |
| CDDP | / | 1.9±0.4 | 1.2±0.3 | 1.2±0.3 | 2.8±0.6 | 7.1±1.3 | 2.6 | 3.0 | 3.4±1.2 | 1.1 |
| OLP | / | 5.9±1.3 | 7.5±1.8 | 4.1±0.7 | 6.7±1.8 | 2.4±0.6 | 0.4 | 4.3 | 4.8±0.7 | 1.0 |
Notes:aThe values of Alog P were predicted by Discovery Studio; bRF=IC50(A549R)/IC50(A549); cAverage IC50 values for four tumor cell lines; dSI = IC50(LO-2)/Average IC50; eNot tested or not calculated.
Abbreviations: NPs, nanoparticles; NPx, naproxen; RF, resistant factor; SI, selectivity index, CDDP, cisplatin; OLP, oxaliplatin.