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. 2021 Aug 5;15:608656. doi: 10.3389/fncel.2021.608656

FIGURE 1.

FIGURE 1

The effect of depression on EPCs numbers and functions. The level of TNF-α, CRP, and IL-6 in peripheral blood of patients with depression are higher than that of healthy subjects, and the level of TNF-α, CRP, and IL-6 have a negative correlation with EPCs numbers. TNF-α and CRP can inhibit the functions of EPCs, such as adhesion, proliferation, migration and angiogenesis in vitro study. Whether depression can affect the above functions of EPCs through TNF-α or other inflammatory factors will require further studies.