FIGURE 2.

CaM directly binds with a series of functional proteins in exocytosis. VAMP2 (Quetglas et al., 2000), myosin Va (Espindola et al., 1992), Munc13-1, ubMunc13-2 (Junge et al., 2004), synapsin 1a, synapsin 2b (Nicol et al., 1997), GAP43 (Baudier et al., 1991), and Rab3A (Park et al., 1997) are all binding partners of CaM. The CaM binding motifs in each protein are labeled using red squares and the corresponding sequence of amino acid is shown. Please note myosin Va consists of six tandem IQ motifs that interact with CaM. Since the size of VAMP2 is relatively small, a 5-times amplification is displayed on its right.