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. 2021 Aug 5;9:673618. doi: 10.3389/fcell.2021.673618

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Copyright © 2021 Mao, Gu, Sui, Shen, Han, Wang, Xi, Zhuang, Meng and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Typical images under a transmission electron microscope. Red arrow indicates the normal mitochondrion, yellow arrow indicates the swollen and abnormal mitochondrion. (B) Quantification of mitochondrial number from the area of 96.9 μm² (n = 3). (C) Quantification of mitochondrial area. (D) Levels of Cyto C, COX IV, TOM20, TIM44, and PRX3 by Western blot. (E) Quantification of (D) C, control, patients with benign disease; NC, patients of non-cachexia; CAC, cancer patients with cachexia. *p < 0.05. Data are displayed as mean ± standard deviation.