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. 2021 Aug 5;9:669145. doi: 10.3389/fcell.2021.669145

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Copyright © 2021 Xu, Xu, Deng, Li, Mu, Qi, Shen, Wang, Wen, Zhao, Weng and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Discrepancy of low and high ZC3H13 expression subgroups in terms of TIME characterization. Comparison of the immune score (ESTIMATE algorithm) between low- and high-ZC3H13 groups in the TCGA cohort (A) and ICGC cohort (B). Difference of immune-related signatures between low- and high-ZC3H13 subgroups in the TCGA cohort (C) and ICGC cohort (D). Distinction of infiltrating immune cell subpopulations and levels between low- and high-ZC3H13 groups in the TCGA cohort (E) and ICGC cohort (F). Comparison of 47 immune checkpoint blockade-related gene expression levels in two ZC3H13 expression subgroups in the TCGA cohort (G) and ICGC cohort (H). The asterisks represented the statistical p value (*P < 0.05; **P < 0.01; ***P < 0.001).