Table 4.

Significant metabolites associated with Crohn’s disease (coded as 1 in logistic regression) at the baseline, one week and 8 weeks after treatment with FDR < 5%. The refitted regression coefficients show the direction of the association.

Disease Stage	HMDB ID	Synonyms	Refitted Coefficient
Baseline	00885	C16:0.cholesteryl ester	4.45
	12097	C14:0.sphingomyelin	1.74
	04953	C24:1.Ceramide.(d18:1)	4.25
	00555	3-methyladipate/pimelate	−12.82
Week 1	06726	C20:4.cholesteryl ester	2.17
	12097	C14:0.sphingomyelin	2.06
	04949	C16:0.Ceramide.(d18:1)	0.87
	00555	3-methyladipate/pimelate	−6.10
	00056	beta-alanine	2.95
	00448	adipate	−4.50
Week 8	00883	valine	1.40
	00222	C16.carnitine	0.58
	00848	C18.carnitine	0.39
	00555	3-methyladipate/pimelate	−5.95
	00056	beta-alanine	0.63