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. 2021 Aug 16;35:20587384211036819. doi: 10.1177/20587384211036819

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© The Author(s) 2021

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — Melatonin decreases oxidative stress and mRNA levels of the NLRP3 inflammasome in db/db mice. (a) Oxidative stress indexes of SOD and MDA were determined using ELISA kits. (b) MMP level in liver tissue was measured. The mRNA levels of (c) NLRP3, (d) caspase-1, (e) IL-1β, and (f) IL-18 in liver were analyzed by real-time PCR. Serum (g) IL-1β and (h) IL-18 concentrations were determined with ELISA. Values are mean ± SD, (n = 6). *p < 0.05 vs db/m, ^#p < 0.05 vs db/db. Abbreviation: MMP: mitochondrial membrane potential; SOD: superoxide dismutase.