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. 2021 Apr 21;88(3):291–316. doi: 10.1177/00243639211005121

Table 24.

Estimated Total Burden of Disease and Economic Costs.

Disease Estimated Excess Cases Estimated Excess Costs
HIV 10,686 US$157,218,081
Breast cancer 452,930 US$10,021,975,916
Cervical cancer 76,581 US$1,052,914,912
Crohn’s disease 81,762 US$1,910,583,605
Ulcerative colitis 40,526 US$522,789,187
Systemic lupus erythematosus 20,385 US$438,985,908
Depression combined oral contraceptives (COCs) 377,733 US$2,413,713,761
Depression progesterone-only contraceptives (POCs) 146,711 US$937,482,772
Interstitial cystitis 12,345 US$89,165,215
Fractures COCs 26,471 US$308,521,992
Fractures POCs 24,926 US$290,517,770
Myocardial Infarction 3,222 US$61,062,935
Cerebrovascular Accident 6,158 US$116,719,504
Hyperthyroidism −1,748 −US$3,956,680
Uterine cancer −198,808 −US$628,302,197
Ovarian cancer −31,487 −US$820,419,141
Totals 1,048,393 US$16,868,973,540