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. 2021 Aug 5;12:698570. doi: 10.3389/fgene.2021.698570

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Copyright © 2021 You, Xu, Wu, Wu, Zhang, Sun and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of DEGs. (A,B) Venn diagram showing a total of 637 DEGs identified by cross-validated comparisons, including 176 downregulated genes (A) and 461 upregulated genes (B). The screening criteria for DEGs was set as | log FC| > 1 and FDR (adjusted P-value) < 0.05 in all four comparisons. (C) Principal component plots of the 637 DEGs showing an overlap between samples from each of the HN or control groups and separation between disease and control in the expression profiles after batch-effect removal. (D) Principal component plot of the 637 DEGs showing a separation between samples from the HN group or control group in independent external dataset GSE99325. DEGs, differentially expressed genes; FC, fold change; FDR, false discovery rate; GSE, Gene Expression Omnibus Series; HN, hypertensive nephropathy; ME, module eigengene.