Table 2.
Cox Regressions for Combined CVD Events
| Treated and Untreated |
| Total CVD | Chi-Square | p-value | HR | 95% CI |
|---|---|---|---|---|
|
| ||||
| Unadjusted | ||||
| DBP<70 vs. 70–89 mm Hg | 238.4 | <.0001 | 5.9 | 4.7–7.4 |
| Age- and Sex-Adjusted | ||||
| DBP<70 vs. 70–89 mm Hg | 190.8 | <.0001 | 5.7 | 4.5–7.3 |
| Age (per SD) | 4.3 | 0.0373 | 1.0 | 1.0–1.0 |
| Sex (male vs. female) | 7.5 | 0.0063 | 0.7 | 0.6–0.9 |
| * Fully Adjusted | ||||
| DBP<70 vs. 70–89 mm Hg | 189.6 | <.0001 | 5.9 | 4.6–7.5 |
| Age (per SD) | 9.1 | 0.0026 | 1.2 | 1.1–1.4 |
| Sex (male vs. female) | 10.8 | 0.001 | 0.7 | 0.6 –0.9 |
| BMI (per SD) | 0.016 | 0.898 | 0.99 | 0.9 –1.1 |
| Total Cholesterol (per SD) | 10.0 | 0.0016 | 1.2 | 1.1 –1.3 |
| Smoking (current vs. other) | 0.8 | 0.3701 | 1.1 | 0.9–1.4 |
| Diabetes (yes vs. no) | 14.1 | 0.0002 | 1.7 | 1.3–2.2 |
| Treated Only |
| Total CVD | Chi-Square | p-value | HR | 95% CI |
|---|---|---|---|---|
|
| ||||
| Unadjusted | ||||
| DBP<70 vs. 70–89 mm Hg | 155.9 | <.0001 | 5.3 | 4.1–6.9 |
| Age- and Sex-Adjusted | ||||
| DBP<70 vs. 70–89 mm Hg | 121.4 | <.0001 | 4.9 | 3.7– 6.5 |
| Age (per SD} | 10.4 | 0.0012 | 1.0 | 1.0–1.0 |
| Sex (male vs. female) | 5.5 | 0.0188 | 0.7 | 0.6–1.0 |
| * Fully Adjusted | ||||
| DBP<70 vs. 70–89 mm Hg | 122.3 | <.0001 | 5.1 | 3.8–6.9 |
| Age (per SD) | 16.4 | <.0001 | 1.4 | 1.2–1.7 |
| Sex (male vs. female) | 9.5 | 0.0021 | 0.7 | 0.5–0.9 |
| BMI (per SD) | 0.4 | 0.5071 | 1.0 | 0.9–1.2 |
| Total Cholesterol (per SD) | 10.4 | 0.0013 | 1.3 | 1.1–1.4 |
| Smoking (current vs. other) | 0.02 | 0.8762 | 0.9 | 0.7–1.3 |
| Diabetes (yes vs. no) | 10.1 | 0.0015 | 1.7 | 1.2–2.3 |
| Treated Only |
| Total CVD | Chi-Square | p-value | HR | 95% CI |
|---|---|---|---|---|
|
| ||||
| Unadjusted | ||||
| DBP < 70 vs. 70–89 mm Hg | 73.8 | <.0001 | 9.2 | 5.5–15.2 |
| Age and sex-adjusted | ||||
| DBP < 70 vs. 70–89 mm Hg | 70.3 | <.0001 | 12.0 | 6.7–21.5 |
| Age (per *SD) | 3.2 | 0.0742 | 0.9 | 0.9–1.0 |
| Sex | 0.7 | 0.4033 | 0.8 | 0.6–1.2 |
| * Fully Adjusted | ||||
| DBP < 70 vs. 70–89 mm Hg | 67.0 | <.0001 | 11.7 | 6.5–21.0 |
| Age (per SD) | 1.6 | 0.2063 | 0.9 | 0.7–1.1 |
| Sex (male vs. female) | 1.4 | 0.2332 | 0.8 | 0.5–1.2 |
| BMI (per SD) | 3.0 | 0.0823 | 0.8 | 0.7–1.0 |
| Total Cholesterol (per SD) | 1.7 | 0.1981 | 1.1 | 0.9–1.3 |
| Smoking (yes vs. no) | 0.7 | 0.3967 | 1.2 | 0.8–1.8 |
| Diabetes (yes vs. no) | 3.9 | 0.0492 | 1.7 | 1.0–2.9 |
N = 791 for all Cox models; Strata (quintiles) were determined using time between primary event and first post-primary event visit; SD = standard deviation;
*
Adjusted for Age per SD, Sex (male vs. female), BMI (per SD), Total Cholesterol (per SD), Smoking (yes vs. no), Diabetes (yes vs. no)