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. 2021 Jun 19;162(10):bqab118. doi: 10.1210/endocr/bqab118

Figure 6.

Figure 6.

Characteristics of the gut microbiota in PCOS mice after treatment with antibiotic cocktails. Intestinal flora analysis of PCOS model mice after antibiotic treatment (20 mg/mL vancomycin, 40 mg/mL neomycin sulfate, 40 mg/mL metronidazole, 40 mg/mL ampicillin intragastrically once daily) removed the intestinal flora for 35 days (control: 7; LET: 5; LET+ABX: 7). (A) Schematic representation of the above experimental design. (B-E) α-diversity of the microbiota in the feces. Data are presented as the mean ± SEM, P < 0.05, Wilcoxon rank-sum test. (F, G) Two-dimensional plot of PCoA for the microbiota. (H) The gut microbiota average relative abundance of the predominant bacterial taxa at the genus level. (I) Differentially abundant taxa identified using LEfSe analysis, P < 0.05, Kruskal-Wallis rank-sum test. ABX, antibiotic treatment; LET, letrozole; PCoA, principal coordinate analysis; PCOS, polycystic ovarian syndrome; SEM, standard error of the mean.