Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jun 19;162(10):bqab118. doi: 10.1210/endocr/bqab118

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

PMC Copyright notice

Figure 7. — Removal of the intestinal flora can improve insulin resistance and suppress the development of PCOS. Phenotype analysis of PCOS model mice after antibiotic treatment (20 mg/mL vancomycin, 40 mg/mL neomycin sulfate, 40 mg/mL metronidazole, 40 mg/mL ampicillin intragastrically once daily) removed the intestinal flora for 35 days (control: 7; LET: 5; LET+ABX: 7). (A-C) Hematoxylin and eosin staining of the ovary, corpus luteum (CL), cystic follicle (CF), and hemorrhagic cyst (HC). (D) Quantitative analysis of cystic follicles. (E) Serum testosterone levels. (F) Fasting blood glucose. (G) HOMA-IR. (H) mRNA levels of ileum FXR. (I) mRNA levels of liver FXR. (J) Serum FGF15 levels. (D-J) P values were determined by 1-way ANOVA for normally distributed data and the Kruskal-Wallis test for nonnormally distributed data. P < 0.05 was considered statistically significant. ABX, antibiotic treatment; FGF15, fibroblast growth factor 15; FXR, farnesoid X receptor; HOMA-IR, homeostasis model assessment for insulin resistance index; LET, letrozole; PCOS, polycystic ovarian syndrome.