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. 2021 Aug 5;9:706832. doi: 10.3389/fcell.2021.706832

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Copyright © 2021 Dai, Lu, Chen, Yang, Sun and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Excess ROS produced by the activation of high glucose causes damage to mitochondria. When the number of damaged mitochondria overwhelms the mitophagy process, the mitochondrial quality control will be damaged. Owning to the rich mitochondrial in the kidney, the loss of MQC exerts an important role in the development of DKD. MQC: mitochondrial quality control; MPQC: mitochondrial protein quality control.