Table 4.

The significant hepatic gene networks associated with NAFLD

ID	Score	Top functions	Focus molecules	Molecules in network
1	39	Cell death, renal necrosis/cell death, renal, and urological disease	18	Akt, AMOTL2, Ap1, Ck2, COL1A1, Collagen(s), CSN2, CXCL12, DCN, DDIT3, DGKZ, ERK, FABP4, FSH, IGFBP3, IL1, IL10, Insulin, ITGA9, Jnk, LDL, MAFB, Mapk, NFkB (complex), P38 MAPK, PI3K, PPFIBP1, RAB3IP, Ras, STAT5a/b, STX4, Tgf beta, ULBP2, UNC5CL, ZAK
2	23	Immunological disease, cancer, cellular growth, and proliferation	12	CD164, CD274, CD33 (includes EG:945), CHI3L2, CTSZ (includes EG:1522), DPP3, FOS, GPNMB, GPR109B, HRSP12, HSP, IFNG, KPNA2, LZTS1, MEFV, MIRN17 (includes EG:406952), MKX, MRPS6 (includes EG:64968), NAT6, NEFM, neuroprotectin D1, NFE2L2, OCM2, PRKACA, PSPN, RBP3, RIF1, SLC15A3, SLC1A4, TGFB1, TNF, TYRP1, USP4, USP25, VIM
3	21	Cellular movement, nervous system development and function, organismal functions	11	ATF6B, CLDN2, CLDN3, CLDN11, DGKD (includes EG:8527), EEF1A2, ERP29, GCHFR, GPR37, HDLBP, HEATR3, HNF4A, HSPA5, INS1, ITGB1, Mg2+, OS9, POLL, RBM42, RGN, SEL1L, SFRS12, SLC2A4, SMAD2, SMUG1, SNRPD3, SSBP1, STXBP4, THRAP3, TMBIM6, TRAF6, TSPAN, TSPAN3, VARS, WNK4
4	21	Lipid metabolism, molecular transport, small molecule biochemistry	11	ALOX5AP, ASF1B, ATP1B1, BICD1, CCNE1, CEP76, CHERP, CLIP1, COIL, DOT1L, DYNC1I1, DYNLL2, EBNA1BP2, FAAH, GABRB2, HIST1H3E, Histone h4, HTR1A, IL4, KLC2, KLHL8, LEPROT, MLLT10, NFIL3, NOC2L, NR3C1, PPP5C, progesterone, SLC1A7, SMARCB1, SS18, TGFBI, TNFSF4, TP53BP1, TP53I3