Figure 2.

Comparison of expression-association relationships at 11 developmental stages within voltage-gated cation channel activity “child” terms. Shown is −log₁₀(P) $\times$ sgn(z) from MAGMA interaction analyses of schizophrenia (A) or bipolar disorder (B) common variant association and BrainSeq-derived gene expression scores at each stage, compared with a background of all genes. Dotted lines indicate thresholds for statistical significance after correcting for analyses of two gene sets across 11 stages. GO:0022843 voltage-gated cation channel activity, n = 125; GO:0005245 voltage-gated calcium channel activity, n = 38; GO:0005249 voltage-gated potassium channel activity, n = 80.