(Panel A) Mean pulmonary arterial pressures (PAP) increased to a greater extent during exercise in patients with heart failure and preserved ejection fraction (HFpEF) compared to patients with non-cardiac dyspnea.
(Panel B) Clinical measures (B-type naturetic peptide levels and echocardiographic E/eā) and the European Society of Cardiology (ESC) diagnostic algorithm42 did not robustly distinguish HFpEF from non-cardiac dyspnea. In contrast, PCWP with leg raise and exercise PASP showed excellent discrimination between HFpEF and NCD.