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. Author manuscript; available in PMC: 2021 Aug 19.
Published in final edited form as: J Invest Dermatol. 2019 Aug 15;140(2):435–444.e4. doi: 10.1016/j.jid.2019.06.146

Figure 1. Il17ra L-SNAs improve the clinical and histological psoriatic phenotype induced by imiquimod inC57BL/6 mice.

Figure 1.

(a) Representative clinical pictures on day 6 before harvesting of back skin. (b) Mean reduction in daily modified Psoriasis Area and Severity Index , as assessed by three blinded reviewers. (c) Routine H&E (above) and Ki67 (below) staining of day 6-harvest mouse skin. Bars = 100 μm. (d) Epidermal thickness from the stratum granulosum to the epidermal-dermal junction. (e) Number of Ki67 + cells per linear length of basal epidermis. (f) Ratio of qRT-PCR levels compared to mouse skin with only vehicle and no IMQ. (g) Representative western blot from harvested skin. Values reported are the mean ± standard error of the mean from three separate experiments. *P < 0.05, ***P < 0.001. H&E, hematoxylin and eosin; IL-17RA, IL-17A receptor; IMQ, imiquimod; qRT-PCR, quantitative real-time reverse transcriptase–PCR; Scr L-SNA, scrambled liposomal spherical nucleic acid.