FIGURE 4.

Sox5 mediated the expression of TRPV1 in neuronal cells in response to capsaicin administration. (A) mRNA level of SOX5 in neuronal cells. Data are mean ± SEM; two-tailed t-test was used for statistical analysis. (B,C) Upregulation of TRPV1 was inhibited after si-SOX5 transfection. Data are mean ± SEM; one-way ANOVA was used for statistical analysis. (D) SOX5 induced the expression of TRPV1 gene, as determined using luciferase assay. Data are mean ± SEM; one-way ANOVA was used for statistical analysis. **P < 0.01; n = 7.