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. 2021 Aug 5;12:629276. doi: 10.3389/fphys.2021.629276

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Copyright © 2021 Ma, Ji, Shi, Li, Wang, Dong, Zhang, Wen, Liu, Wang and Luo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sinomenine reduced the protein level of TRPV1 via downregulating SOX5 expression in neuronal cells. (A,B) Effect of sinomenine treatment and SOX5 administration on the protein expression levels of TRPV1 and SOX5 in neuronal cells. Data are mean ± SEM; one-way ANOVA was used for statistical analysis. (C,D) Effect of sinomenine treatment and SOX5 administration on the protein levels of SP and NKA in neuronal cells. Data are mean ± SEM; one-way ANOVA was used for statistical analysis. (E) Intracellular calcium levels in neuronal cells. Data are mean ± SEM; one-way ANOVA was used for statistical analysis. **P < 0.01; n = 7.